THE INFECTION IS SPREADING.
FRANK HAS THE CURE.
A terrible plague has swept the Earth, turning everyone – human, hero, villain, god and monster — into sadistic cannibal predators. As Spider-Man, the Hulk, the Thing and other infected start a feeding frenzy, the world falls in a wave of insatiable violence. Now, five years later, one man hunts the wasteland that was New York City. One man stands against the hordes of monsters who hunt the night. He is the Punisher, the Last Gun on Earth.
In this alternate universe, Castle is the sole member of the Marvel Universe unaffected by a pathogen that transforms its entire metahuman population (as well as regular humans) into homicidal cannibals. Spider-Man, The Blob, Daredevil, The Thing, The Hulk, Iron Man, Magneto, Hawkeye, Cyclops, Kingpin, Scorpion, Namor, Ant-Man, Doctor Octopus, Moon Knight, Emma Frost, Luke Cage, Rogue, Gambit, Iron Fist and others are hunted and killed in a New York City that has been depopulated. At the end, a pregnant Mary Jane Parker looks on aghast as Castle kills Spider-Man, who had become the cannibal king of New York City.
Start of the Infection
The Punisher had gotten a tip that the Red Mafia had smuggled what he assumed was a suitcase nuke. In actuality, they had imported vials of Survivor 118, a chemical that could be released through the water or air and allow people to adapt to live in a contaminated environment and eat anything. His mistake resulted his accidental exposure of the chemical, causing him to be sick for days, but protecting him from future ills and giving him an immunity to the chemical.
The chemical entered New York’s water but no symptoms showed for seven months. In that time, people’s movements around the world quickly spread the virus to every part of the planet. The first known case was during an aggressive battle between Spider-Man and the Rhino, during which their fight ended in a hockey stadium, where Spider-Man ate the Rhino on live television. The Fantastic Four captured him and brought together a science team consisting of Reed Richards, Hank Pym, T’Challa, and Hank McCoy to figure out what has happened to him. They learned that Spider-Man’s DNA had been completely rewritten, leaving him as he was but primitive and predatorial human being.